anti- POFUT1 antibody

Product Description

anti- POFUT1 antibody is available at Gentaur for Next week Delivery.

Purification: Immunogen affinity purified

Background: Catalyzes the reaction that attaches fucose through an O-glycosidic linkage to a conserved serine or threonine residue found in the consensus sequence C2-X(4,5)-[S/T]-C3 of EGF domains, where C2 and C3 are the second and third conserved cysteines. Specifically uses GDP-fucose as donor substrate and proper disulfide pairing of the substrate EGF domains is required for fucose transfer. Plays a crucial role in NOTCH signaling. Initial fucosylation of NOTCH by POFUT1 generates a substrate for FRINGE/RFNG, an acetylglucosaminyltransferase that can then extend the fucosylation on the NOTCH EGF repeats. This extended fucosylation is required for optimal ligand binding and canonical NOTCH signaling induced by DLL1 or JAGGED1. Fucosylates AGRN and determines its ability to cluster acetylcholine receptors(AChRs)..

Immunogen: protein O-fucosyltransferase 1

Synonyms: FUT12, KIAA0180

Reactivity: Human, Mouse, Rat

Tested Application: ELISA, WB, IHC, IF, IP

Recommended dilution:

Image 1: Immunohistochemistry of paraffin-embedded human liver cancer using FNab06602(POFUT1 antibody) at dilution of 1:50

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Image 4: HepG2 cells were subjected to SDS PAGE followed by western blot with FNab06602(POFUT1 antibody) at dilution of 1:500

Gene ID: 23509

Research Area: Metabolism

Uniprot ID: Q9H488