anti- RAB10 antibody

Product Description

anti- RAB10 antibody is available at Gentaur for Next week Delivery.

Purification: Immunogen affinity purified

Background: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion(By similarity). That Rab is mainly involved in the biosynthetic transport of proteins from the Golgi to the plasma membrane. Regulates, for instance, SLC2A4/GLUT4 glucose transporter-enriched vesicles delivery to the plasma membrane. In parallel, it regulates the transport of TLR4, a toll-like receptor to the plasma membrane and therefore may be important for innate immune response. Plays also a specific role in asymmetric protein transport to the plasma membrane within the polarized neuron and epithelial cells. In neurons, it is involved in axonogenesis through regulation of vesicular membrane trafficking toward the axonal plasma membrane while in epithelial cells, it regulates transport from the Golgi to the basolateral membrane. Moreover, may play a role in the basolateral recycling pathway and in phagosome maturation. According to PubMed:23263280, may play a role in endoplasmic reticulum dynamics and morphology controlling tubulation along microtubules and tubules fusion..

Immunogen: RAB10, member RAS oncogene family

Synonyms:

Reactivity: Human, Mouse, Rat

Tested Application: ELISA, WB, IHC

Recommended dilution:

Image 1: Immunohistochemistry of paraffin-embedded human prostate cancer using FNab06987(RAB10 antibody) at dilution of 1:100

Image 2: .

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Image 4: human brain tissue were subjected to SDS PAGE followed by western blot with FNab06987(RAB10 antibody) at dilution of 1:400

Gene ID: 10890

Research Area: Metabolism

Uniprot ID: P61026