anti- RAB5A antibody

Product Description

anti- RAB5A antibody is available at Gentaur for Next week Delivery.

Purification: Immunogen affinity purified

Background: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB5A is required for the fusion of plasma membranes and early endosomes(PubMed:10818110, PubMed:14617813, PubMed:16410077, PubMed:15378032). Contributes to the regulation of filopodia extension(PubMed:14978216). Required for the exosomal release of SDCBP, CD63, PDCD6IP and syndecan(PubMed:22660413). Regulates maturation of apoptotic cell-containing phagosomes, probably downstream of DYN2 and PIK3C3(By similarity)..

Immunogen: RAB5A, member RAS oncogene family

Synonyms: RAB5, RAB5A, Ras related protein Rab 5A

Reactivity: Human, Mouse, Rat

Tested Application: ELISA, IHC, WB, IP,IF

Recommended dilution: WB: 1:200-1:2000; IP:1:200-1:2000; IHC: 1:50-1:500; IF: 1:50-1:500

Image 1: Immunohistochemistry of paraffin-embedded human gliomas tissue slide using FNab07038(RAB5A Antibody) at dilution of 1:200 heat mediated antigen retrieved with Tris-EDTA buffer(pH9).

Image 2: Immunofluorescent analysis of ( -20? Ethanol ) fixed HeLa cells using FNab07038( RAB5A Antibody) at dilution of 1:50 and Alexa Fluor 488-congugated Goat Anti-Rabbit IgG(H+L).

Image 3:

Image 4: mouse brain tissue were subjected to SDS PAGE followed by western blot with FNab07038(RAB5A antibody) at dilution of 1:500

Gene ID: 5868

Research Area: Metabolism

Uniprot ID: P20339