anti- RWDD3 antibody

Product Description

anti- RWDD3 antibody is available at Gentaur for Next week Delivery.

Purification: Immunogen affinity purified

Background: Enhancer of SUMO conjugation. Via its interaction with UBE2I/UBC9, increases SUMO conjugation to proteins by promoting the binding of E1 and E2 enzymes, thioester linkage between SUMO and UBE2I/UBC9 and transfer of SUMO to specific target proteins which include HIF1A, PIAS, NFKBIA, NR3C1 and TOP1. Isoform 1 and isoform 2 positively regulate the NF-kappa-B signaling pathway by enhancing the sumoylation of NF-kappa-B inhibitor alpha(NFKBIA), promoting its stabilization which consequently leads to an increased inhibition of NF-kappa-B transcriptional activity. Isoform 1 and isoform 2 negatively regulate the hypoxia-inducible factor-1 alpha(HIF1A) signaling pathway by increasing the sumoylation of HIF1A, promoting its stabilization, transcriptional activity and the expression of its target gene VEGFA during hypoxia. Isoform 2 promotes the sumoylation and transcriptional activity of the glucocorticoid receptor NR3C1 and enhances the interaction of SUMO1 and NR3C1 with UBE2I/UBC9. Has no effect on ubiquitination..

Immunogen: RWD domain containing 3

Synonyms: RSUME

Reactivity: Human

Tested Application: ELISA, IHC

Recommended dilution:

Image 1: Immunohistochemistry of paraffin-embedded human liver using FNab07540(RWDD3 antibody) at dilution of 1:50

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Gene ID: 25950

Research Area: Metabolism

Uniprot ID: Q9Y3V2