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Product Description
anti- SCAP antibody is available at Gentaur for Next week Delivery.
Purification: Immunogen affinity purified
Background: Escort protein required for cholesterol as well as lipid homeostasis. Regulates export of the SCAP/SREBF complex from the ER upon low cholesterol. Formation of a ternary complex with INSIG at high sterol concentrations leads to masking of an ER-export signal in SCAP and retention of the complex in the ER. Low sterol concentrations trigger release of INSIG, a conformational change in the SSC domain of SCAP, unmasking of the ER export signal, recruitment into COPII-coated vesicles, transport to the Golgi complex, proteolytic cleavage of SREBF in the Golgi, release of the transcription factor fragment of SREBF from the membrane, its import into the nucleus and up-regulation of LDLR, INSIG1 and the mevalonate pathway(By similarity)..
Immunogen: SREBF chaperone
Synonyms: KIAA0199
Reactivity: Human, Mouse
Tested Application: ELISA, WB, IHC, IF
Recommended dilution:
Image 1: Immunohistochemistry of paraffin-embedded human lung cancer tissue slide using FNab07622(SCAP Antibody) at dilution of 1:50
Image 2: .
Image 3:
Image 4: HEK-293 cells were subjected to SDS PAGE followed by western blot with FNab07622(SCAP antibody) at dilution of 1:300
Gene ID: 22937
Research Area: Metabolism
Uniprot ID: Q12770
