anti- SETMAR antibody

Product Description

anti- SETMAR antibody is available at Gentaur for Next week Delivery.

Purification: Immunogen affinity purified

Background: Protein derived from the fusion of a methylase with the transposase of an Hsmar1 transposon that plays a role in DNA double-strand break repair, stalled replication fork restart and DNA integration. DNA-binding protein, it is indirectly recruited to sites of DNA damage through protein-protein interactions. Has also kept a sequence-specific DNA-binding activity recognizing the 19-mer core of the 5'-terminal inverted repeats(TIRs) of the Hsmar1 element and displays a DNA nicking and end joining activity(PubMed:16332963, PubMed:16672366, PubMed:17877369, PubMed:17403897, PubMed:18263876, PubMed:22231448, PubMed:24573677, PubMed:20521842). In parallel, has a histone methyltransferase activity and methylates 'Lys-4' and 'Lys-36' of histone H3. Specifically mediates dimethylation of H3 'Lys-36' at sites of DNA double-strand break and may recruit proteins required for efficient DSB repair through non-homologous end-joining(PubMed:16332963, PubMed:21187428, PubMed:22231448). Also regulates replication fork processing, promoting replication fork restart and regulating DNA decatenation through stimulation of the topoisomerase activity of TOP2A(PubMed:18790802, PubMed:20457750)..

Immunogen: SET domain and mariner transposase fusion gene

Synonyms:

Reactivity: Human

Tested Application: ELISA, WB, IP

Recommended dilution:

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Image 4: HL-60 cells were subjected to SDS PAGE followed by western blot with FNab07773( SETMAR Antibody) at dilution of 1:600

Gene ID: 6419

Research Area: Metabolism

Uniprot ID: Q53H47