anti- SGMS1 antibody

Product Description

anti- SGMS1 antibody is available at Gentaur for Next week Delivery.

Purification: Immunogen affinity purified

Background: Sphingomyelin synthases synthesize the sphingolipid, sphingomyelin, through transfer of the phosphatidyl head group, phosphatidylcholine, on to the primary hydroxyl of ceramide. The reaction is bidirectional depending on the respective levels of the sphingolipid and ceramide. Golgi apparatus SMS1 directly and specifically recognizes the choline head group on the substrate, requiring two fatty chains on the choline-P donor molecule in order to be recognized efficiently as a substrate. Major form in macrophages. Required for cell growth in certain cell types such as HeLa cells. Suppresses BAX-mediated apoptosis and also prevents cell death in response to stimuli such as hydrogen peroxide, osmotic stress, elevated temperature and exogenously supplied sphingolipids. May protect against cell death by reversing the stress-inducible increase in levels of proapoptotic ceramide..

Immunogen: sphingomyelin synthase 1

Synonyms: MOB, SMS1, TMEM23

Reactivity: Human, Mouse, Rat

Tested Application: ELISA, WB, IHC

Recommended dilution:

Image 1: Immunohistochemistry of paraffin-embedded human liver using FNab07811(SGMS1 antibody) at dilution of 1:50

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Image 4: human heart tissue were subjected to SDS PAGE followed by western blot with FNab07811(SGMS1 antibody) at dilution of 1:300

Gene ID: 259230

Research Area: Metabolism

Uniprot ID: Q86VZ5