anti- SIRT5 antibody

Product Description

anti- SIRT5 antibody is available at Gentaur for Next week Delivery.

Purification: Immunogen affinity purified

Background: NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins(PubMed:21908771, PubMed:22076378, PubMed:24703693). Activates CPS1 and contributes to the regulation of blood ammonia levels during prolonged fasting: acts by mediating desuccinylation and deglutarylation of CPS1, thereby increasing CPS1 activity in response to elevated NAD levels during fasting(PubMed:22076378, PubMed:24703693). Activates SOD1 by mediating its desuccinylation, leading to reduced reactive oxygen species(PubMed:24140062). Modulates ketogenesis through the desuccinylation and activation of HMGCS2(By similarity). Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo. Can deacetylate cytochrome c(CYCS) and a number of other proteins in vitro such as UOX..

Immunogen: sirtuin(silent mating type information regulation 2 homolog) 5

Synonyms: FLJ36950, SIR2 like protein 5, SIR2L5, SIRT5

Reactivity: Human, Mouse, Rat

Tested Application: ELISA, WB, IP

Recommended dilution: WB: 1:500-1:1000; IP: 1:500-1:1000; IF: 1:50-1:500

Image 1:

Image 2: .

Image 3: IP Result of anti-SIRT5 (IP: FNab07883, 4ug; Detection: FNab07883 1:500) with mouse liver tissue lysate 6000ug.

Image 4: HeLa cells were subjected to SDS PAGE followed by western blot with FNab07883(SIRT5 antibody) at dilution of 1:600

Gene ID:

Research Area: Metabolism

Uniprot ID: Q9NXA8