anti- SMAD2 antibody

Product Description

anti- SMAD2 antibody is available at Gentaur for Next week Delivery.

Purification: Immunogen affinity purified

Background: The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signal of the transforming growth factor (TGF)-beta, and thus regulates multiple cellular processes, such as cell proliferation, apoptosis, and differentiation. This protein is recruited to the TGF-beta receptors through its interaction with the SMAD anchor for receptor activation (SARA) protein. In response to TGF-beta signal, this protein is phosphorylated by the TGF-beta receptors. The phosphorylation induces the dissociation of this protein with SARA and the association with the family member SMAD4. The association with SMAD4 is important for the translocation of this protein into the nucleus, where it binds to target promoters and forms a transcription repressor complex with other cofactors. This protein can also be phosphorylated by activin type 1 receptor kinase, and mediates the signal from the activin. Alternatively spliced transcript variants have been observed for this gene..

Immunogen: SMAD family member 2

Synonyms: MADH2, MADR2, hMAD 2, hSMAD2, JV18, JV18 1, MAD homolog 2, Mad related protein 2, Mothers against DPP homolog 2, SMAD 2, SMAD family member 2, SMAD2

Reactivity: Human, Rat

Tested Application: ELISA, WB, IHC

Recommended dilution: WB: 1:500 - 1:2000; IHC: 1:50 - 1:100

Image 1: Immunohistochemistry of paraffin-embedded human endometrial cancer tissue slide using FNab07993( SMAD2 Antibody) at dilution of 1:50

Image 2: Immunofluorescent analysis of HepG2 cells, using SMAD2 antibody FNab07993 at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IgG (red)..

Image 3: IP Result of anti-SMAD2 (IP: FNab07993, 3ug; Detection:1FNab07993 1:1000) with HepG2 cells lysate 3000ug.

Image 4: HeLa cells were subjected to SDS PAGE followed by western blot with FNab07993(SMAD2 antibody) at dilution of 1:1000

Gene ID: 4087

Research Area: Metabolism

Uniprot ID: Q15796