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Product Description
anti- SMAD7 antibody is available at Gentaur for Next week Delivery.
Purification: Immunogen affinity purified
Background: Antagonist of signaling by TGF-beta(transforming growth factor) type 1 receptor superfamily members; has been shown to inhibit TGF-beta(Transforming growth factor) and activin signaling by associating with their receptors thus preventing SMAD2 access. Functions as an adapter to recruit SMURF2 to the TGF-beta receptor complex. Also acts by recruiting the PPP1R15A-PP1 complex to TGFBR1, which promotes its dephosphorylation. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator(By similarity)..
Immunogen: SMAD family member 7
Synonyms: MADH7, MADH8
Reactivity: Human, Mouse
Tested Application: ELISA, WB
Recommended dilution:
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Image 4: mouse liver tissue were subjected to SDS PAGE followed by western blot with FNab07999(SMAD7 antibody) at dilution of 1:600
Gene ID: 4092
Research Area: Metabolism
Uniprot ID: O15105
