anti- SMARCA5 antibody

Product Description

anti- SMARCA5 antibody is available at Gentaur for Next week Delivery.

Purification: Immunogen affinity purified

Background: Helicase that possesses intrinsic ATP-dependent nucleosome-remodeling activity. Complexes containing SMARCA5 are capable of forming ordered nucleosome arrays on chromatin; this may require intact histone H4 tails. Also required for replication of pericentric heterochromatin in S-phase specifically in conjunction with BAZ1A. Probably plays a role in repression of polI dependent transcription of the rDNA locus, through the recruitment of the SIN3/HDAC1 corepressor complex to the rDNA promoter. Essential component of the WICH complex, a chromatin remodeling complex that mobilizes nucleosomes and reconfigures irregular chromatin to a regular nucleosomal array structure. The WICH complex regulates the transcription of various genes, has a role in RNA polymerase I and RNA polymerase III transcription, mediates the histone H2AX phosphorylation at 'Tyr-142', and is involved in the maintenance of chromatin structures during DNA replication processes. Essential component of the NoRC(nucleolar remodeling complex) complex, a complex that mediates silencing of a fraction of rDNA by recruiting histone-modifying enzymes and DNA methyltransferases, leading to heterochromatin formation and transcriptional silencing..

Immunogen: SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5

Synonyms: SNF2H, WCRF135

Reactivity: Human, Mouse, Rat

Tested Application: ELISA, WB

Recommended dilution:

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Image 4: HepG2 cells were subjected to SDS PAGE followed by western blot with FNab08006(SMARCA5 antibody) at dilution of 1:800

Gene ID: 8467

Research Area: Metabolism

Uniprot ID: O60264