anti- SMARCD1 antibody

Product Description

anti- SMARCD1 antibody is available at Gentaur for Next week Delivery.

Purification: Protein A+G purification

Background: Involved in chromatin remodeling. Belongs to the neural progenitors-specific chromatin remodeling complex(npBAF complex) and the neuron-specific chromatin remodeling complex(nBAF complex). During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes(nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth(By similarity). Has a strong influence on vitamin D-mediated transcriptional activity from an enhancer vitamin D receptor element(VDRE). May be a link between mammalian SWI-SNF-like chromatin remodeling complexes and the vitamin D receptor(VDR) heterodimer. Mediates critical interactions between nuclear receptors and the BRG1/SMARCA4 chromatin-remodeling complex for transactivation..

Immunogen: SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1

Synonyms: BAF60A

Reactivity: Human

Tested Application: ELISA, WB

Recommended dilution: WB: 1:500-1:2000

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Image 4: Jurkat cells were subjected to SDS PAGE followed by western blot with FNab08011(SMARCD1 antibody) at dilution of 1:1000

Gene ID: 6602

Research Area: Metabolism

Uniprot ID: Q96GM5