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Product Description
anti- SMC6 antibody is available at Gentaur for Next week Delivery.
Purification: Immunogen affinity purified
Background: Core component of the SMC5-SMC6 complex, a complex involved in DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT(alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex(telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies(APBs). Required for recruitment of telomeres to PML nuclear bodies. SMC5-SMC6 complex may prevent transcription of episomal DNA, such as circular viral DNA genome(PubMed:26983541)..
Immunogen: structural maintenance of chromosomes 6
Synonyms: SMC6L1
Reactivity: Human, Mouse, Rat
Tested Application: ELISA, WB
Recommended dilution:
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Image 4: NIH/3T3 cells were subjected to SDS PAGE followed by western blot with FNab08020(SMC6 antibody) at dilution of 1:2000
Gene ID: 79677
Research Area: Metabolism
Uniprot ID: Q96SB8
