anti- SNX3 antibody

Product Description

anti- SNX3 antibody is available at Gentaur for Next week Delivery.

Purification: Immunogen affinity purified

Background: Phosphoinositide-binding protein required for multivesicular body formation. Specifically binds phosphatidylinositol 3-phosphate(PtdIns(P3)). Also can bind phosphatidylinositol 4-phosphate(PtdIns(P4)), phosphatidylinositol 5-phosphate(PtdIns(P5)) and phosphatidylinositol 3,5-biphosphate(PtdIns(3,5)P2)(By similarity). Plays a role in protein transport between cellular compartments. Together with RAB7A facilitates endosome membrane association of the retromer cargo-selective subcomplex(CSC/VPS). May in part act as component of the SNX3-retromer complex which mediates the retrograde endosome-to-TGN transport of WLS distinct from the SNX-BAR retromer pathway(PubMed:21725319, PubMed:24344282). Promotes stability and cell surface expression of epithelial sodium channel(ENAC) subunits SCNN1A and SCNN1G(By similarity). Not involved in EGFR degradation. Involved in the regulation of phagocytosis in dendritic cells possibly by regulating EEA1 recruitment to the nascent phagosomes(PubMed:23237080). Involved in iron homeostasis through regulation of endocytic recycling of the transferrin receptor TFRC presumably by delivering the tranferrin:transferrin receptor complex to recycling endosomes; the function may involve the CSC retromer subcomplex(By similarity). In the case of Salmonella enterica infection plays arole in maturation of the Salmonella-containing vacuole(SCV) and promotes recruitment of LAMP1 to SCVs(PubMed:20482551)..

Immunogen: sorting nexin 3

Synonyms:

Reactivity: Human, Mouse, Rat

Tested Application: ELISA, WB, IF

Recommended dilution:

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Image 4: COLO 320 cells were subjected to SDS PAGE followed by western blot with FNab08091(SNX3 antibody) at dilution of 1:500

Gene ID: 8724

Research Area: Metabolism

Uniprot ID: O60493