anti- SPOP antibody

Product Description

anti- SPOP antibody is available at Gentaur for Next week Delivery.

Purification: Immunogen affinity purified

Background: Component of a cullin-RING-based BCR(BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, leading most often to their proteasomal degradation. In complex with CUL3, involved in ubiquitination and proteasomal degradation of BRMS1, DAXX, PDX1/IPF1, GLI2 and GLI3. In complex with CUL3, involved in ubiquitination of H2AFY and BMI1; this does not lead to their proteasomal degradation. Inhibits transcriptional activation of PDX1/IPF1 targets, such as insulin, by promoting PDX1/IPF1 degradation. The cullin-RING-based BCR(BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex containing homodimeric SPOP has higher ubiquitin ligase activity than the complex that contains the heterodimer formed by SPOP and SPOPL..

Immunogen: speckle-type POZ protein

Synonyms: HIB homolog 1, Roadkill homolog 1, speckle type POZ protein, SPOP, TEF2

Reactivity: Human, Mouse, Rat

Tested Application: ELISA, WB, IHC, IP

Recommended dilution: WB: 1:500-1:2000; IHC: 1:50-1:500; IP : 1:500-1:1000

Image 1: Immunohistochemistry of paraffin-embedded human prostate cancer tissue slide using FNab08189( SPOP Antibody) at dilution of 1:200

Image 2: .

Image 3: IP Result of anti-SPOP (IP:FNab08189, 3ug; Detection:FNab08189 1:500) with HeLa cell lysate 3000ug.

Image 4: HeLa cells were subjected to SDS PAGE followed by western blot with FNab08189 (SPOP antibody) at dilution of 1:500

Gene ID: 8405

Research Area: Metabolism

Uniprot ID: O43791