anti- TBC1D5 antibody

Product Description

anti- TBC1D5 antibody is available at Gentaur for Next week Delivery.

Purification: Immunogen affinity purified

Background: May act as a GTPase-activating protein(GAP) for Rab family protein(s). May act as a GAP for RAB7A. Can displace RAB7A and retromer CSC subcomplex from the endosomal membrane to the cytosol; at least retromer displacement seems to require its catalytic activity(PubMed:19531583, PubMed:20923837). Required for retrograde transport of cargo proteins from endosomes to the trans-Golgi network(TGN); the function seems to require its catalytic activity. Involved in regulation of autophagy(PubMed:22354992). May act as a molecular switch between endosomal and autophagosomal transport and is involved in reprogramming vesicle trafficking upon autophagy induction. Involved in the trafficking of ATG9A upon activation of autophagy. May regulate the recruitment of ATG9A-AP2-containing vesicles to autophagic membranes(PubMed:24603492)..

Immunogen: TBC1 domain family, member 5

Synonyms: KIAA0210

Reactivity: Human, Mouse, Rat

Tested Application: ELISA, WB, IHC, IP

Recommended dilution: WB: 1:500-1:2400; IP: 1:200-1:1000 ; IHC: 1:20-1:200

Image 1: Immunohistochemistry of paraffin-embedded human kidney using FNab08515(TBC1D5 antibody) at dilution of 1:100

Image 2: .

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Image 4: A431 cells were subjected to SDS PAGE followed by western blot with FNab08515(TBC1D5 antibody) at dilution of 1:400

Gene ID: 9779

Research Area: Metabolism

Uniprot ID: Q92609