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Product Description
anti- TCF7L2 antibody is available at Gentaur for Next week Delivery.
Purification: Immunogen affinity purified
Background: Participates in the Wnt signaling pathway and modulates MYC expression by binding to its promoter in a sequence-specific manner. Acts as repressor in the absence of CTNNB1, and as activator in its presence. Activates transcription from promoters with several copies of the Tcf motif 5'-CCTTTGATC-3' in the presence of CTNNB1. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by TCF7L2/TCF4 and CTNNB1. Expression of dominant-negative mutants results in cell-cycle arrest in G1. Necessary for the maintenance of the epithelial stem-cell compartment of the small intestine..
Immunogen: transcription factor 7-like 2(T-cell specific, HMG-box)
Synonyms: TCF4
Reactivity: Human, Mouse, Rat
Tested Application: ELISA, WB, IP
Recommended dilution:
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Image 4: mouse liver tissue were subjected to SDS PAGE followed by western blot with FNab08556(TCF7L2 antibody) at dilution of 1:1000
Gene ID: 6934
Research Area: Metabolism
Uniprot ID: Q9NQB0
