anti- TGFBRAP1 antibody

Product Description

anti- TGFBRAP1 antibody is available at Gentaur for Next week Delivery.

Purification: Immunogen affinity purified

Background: Plays a role in the TGF-beta/activin signaling pathway. It associates with inactive heteromeric TGF-beta and activin receptor complexes, mainly through the type II receptor, and is released upon activation of signaling. May recruit SMAD4 to the vicinity of the receptor complex and facilitate its interaction with receptor-regulated Smads, such as SMAD2. Plays a role in vesicle-mediated protein trafficking of the endocytic membrane transport pathway. Believed to act as a component of the putative CORVET endosomal tethering complexes which is proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The CORVET complex is proposed to function as a Rab5 effector to mediate early endosome fusion probably in specific endosome subpopulations(PubMed:25266290). Functions predominantly in APPL1-containing endosomes and in degradative but not recycling trafficking of endocytosed cargo(PubMed:25266290)..

Immunogen: transforming growth factor, beta receptor associated protein 1

Synonyms:

Reactivity: Human

Tested Application: ELISA, WB, IHC, IF

Recommended dilution:

Image 1: Immunohistochemistry of paraffin-embedded human kidney tissue slide using FNab08646(TGFBRAP1 Antibody) at dilution of 1:50

Image 2: .

Image 3:

Image 4: HEK-293 cells were subjected to SDS PAGE followed by western blot with FNab08646(TGFBRAP1 antibody) at dilution of 1:300

Gene ID: 9392

Research Area: Metabolism

Uniprot ID: Q8WUH2