anti- TNIP2 antibody

Product Description

anti- TNIP2 antibody is available at Gentaur for Next week Delivery.

Purification: Immunogen affinity purified

Background: Inhibits NF-kappa-B activation by blocking the interaction of RIPK1 with its downstream effector NEMO/IKBKG. Forms a ternary complex with NFKB1 and MAP3K8 but appears to function upstream of MAP3K8 in the TLR4 signaling pathway that regulates MAP3K8 activation. Involved in activation of the MEK/ERK signaling pathway during innate immune response; this function seems to be stimulus-and cell type specific. Required for stability of MAP3K8. Involved in regulation of apoptosis in endothelial cells; promotes TEK agonist-stimulated endothelial survival. May act as transcriptional coactivator when translocated to the nucleus. Enhances CHUK-mediated NF-kappa-B activation involving NF-kappa-B p50-p65 and p50-c-Rel complexes..

Immunogen: TNFAIP3 interacting protein 2

Synonyms: ABIN2, FLIP1

Reactivity: Human, Mouse, Rat

Tested Application: ELISA, WB, IF, IHC

Recommended dilution:

Image 1: Immunohistochemistry of paraffin-embedded human liver using FNab08832(TNIP2 antibody) at dilution of 1:100

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Image 4: HepG2 cells were subjected to SDS PAGE followed by western blot with FNab08832(TNIP2 antibody) at dilution of 1:500

Gene ID: 79155

Research Area: Metabolism

Uniprot ID: Q8NFZ5