anti- TPX2 antibody

Product Description

anti- TPX2 antibody is available at Gentaur for Next week Delivery.

Purification: Immunogen affinity purified

Background: Spindle assembly factor required for normal assembly of mitotic spindles. Required for normal assembly of microtubules during apoptosis. Required for chromatin and/or kinetochore dependent microtubule nucleation. Mediates AURKA localization to spindle microtubules(PubMed:18663142, PubMed:19208764). Activates AURKA by promoting its autophosphorylation at 'Thr-288' and protects this residue against dephosphorylation(PubMed:18663142, PubMed:19208764). TPX2 is inactivated upon binding to importin-alpha(PubMed:26165940). At the onset of mitosis, GOLGA2 interacts with importin-alpha, liberating TPX2 from importin-alpha, allowing TPX2 to activates AURKA kinase and stimulates local microtubule nucleation(PubMed:26165940)..

Immunogen: TPX2, microtubule-associated, homolog(Xenopus laevis)

Synonyms: C20orf1, C20orf2, DIL2, HCA519

Reactivity: Human, Mouse, Rat

Tested Application: ELISA, WB, IF, IP

Recommended dilution:

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Image 4: HepG2 cells were subjected to SDS PAGE followed by western blot with FNab08910(TPX2 antibody) at dilution of 1:5000

Gene ID:

Research Area: Metabolism

Uniprot ID: Q9ULW0