anti- TRIM11 antibody

Product Description

anti- TRIM11 antibody is available at Gentaur for Next week Delivery.

Purification: Immunogen affinity purified

Background: E3 ubiquitin-protein ligase that promotes the degradation of insoluble ubiquitinated proteins, including insoluble PAX6, poly-Gln repeat expanded HTT and poly-Ala repeat expanded ARX. Mediates PAX6 ubiquitination leading to proteasomal degradation, thereby modulating cortical neurogenesis. May also inhibit PAX6 transcriptional activity, possibly in part by preventing the binding of PAX6 to its consensus sequences. May contribute to the regulation of the intracellular level of HN(humanin) or HN-containing proteins through the proteasomal degradation pathway. Mediates MED15 ubiquitination leading to proteasomal degradation. May contribute to the innate restriction of retroviruses. Upon overexpression, reduces HIV-1 and murine leukemia virus infectivity, by suppressing viral gene expression. Antiviral activity depends on a functional E3 ubiquitin-protein ligase domain. May regulate TRIM5 turnover via the proteasome pathway, thus counteracting the TRIM5-mediated cross-species restriction of retroviral infection at early stages of the retroviral life cycle..

Immunogen: tripartite motif-containing 11

Synonyms: BIA1, Protein BIA1, RING finger protein 92, RNF92, TRIM11, tripartite motif containing 11

Reactivity: Human

Tested Application: ELISA, WB, IHC

Recommended dilution: WB: 1:200-1:1000; IHC: 1:20-1:200

Image 1: Immunohistochemistry of paraffin-embedded human ovary tumor using FNab08967(TRIM11 antibody) at dilution of 1:100

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Image 4: HEK-293 cells were subjected to SDS PAGE followed by western blot with FNab08967(TRIM11 antibody) at dilution of 1:100

Gene ID: 81559

Research Area: Metabolism

Uniprot ID: Q96F44