anti- TRIM24 antibody

Product Description

anti- TRIM24 antibody is available at Gentaur for Next week Delivery.

Purification: Immunogen affinity purified

Background: Transcriptional coactivator that interacts with numerous nuclear receptors and coactivators and modulates the transcription of target genes. Interacts with chromatin depending on histone H3 modifications, having the highest affinity for histone H3 that is both unmodified at 'Lys-4'(H3K4me0) and acetylated at 'Lys-23'(H3K23ac). Has E3 protein-ubiquitin ligase activity. Promotes ubiquitination and proteasomal degradation of p53/TP53. Plays a role in the regulation of cell proliferation and apoptosis, at least in part via its effects on p53/TP53 levels. Up-regulates ligand-dependent transcription activation by AR, GCR/NR3C1, thyroid hormone receptor(TR) and ESR1. Modulates transcription activation by retinoic acid(RA) receptors, including RARA. Plays a role in regulating retinoic acid-dependent proliferation of hepatocytes(By similarity)..

Immunogen: tripartite motif-containing 24

Synonyms: HTIF1, PTC6, RING finger protein 82, RNF82, TF1A, TIF1, TIF1 alpha, TIF1A, TIF1ALPHA, TRIM24, tripartite motif containing 24

Reactivity: Human, Mouse, Rat

Tested Application: ELISA, WB, IHC, IP

Recommended dilution: WB: 1:500-1:5000; IP: 1:200-1:2000; IHC: 1:50-1:200; IF: 1:50-1:500

Image 1: Immunohistochemistry of paraffin-embedded human prostate cancer using FNab08975(TRIM24 antibody) at dilution of 1:100

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Image 4: HeLa cells were subjected to SDS PAGE followed by western blot with FNab08975(TRIM24 antibody) at dilution of 1:500

Gene ID: 8805

Research Area: Metabolism

Uniprot ID: O15164