anti- TRIM27 antibody

Product Description

anti- TRIM27 antibody is available at Gentaur for Next week Delivery.

Purification: Immunogen affinity purified

Background: E3 ubiquitin-protein ligase that mediates ubiquitination of PIK3C2B and inhibits its activity; mediates the formation of 'Lys-48'-linked polyubiquitin chains; the function inhibits CD4 T-cell activation. Acts as a regulator of retrograde transport: together with MAGEL2, mediates the formation of 'Lys-63'-linked polyubiquitin chains at 'Lys-220' of WASH1, leading to promote endosomal F-actin assembly(PubMed:23452853). Has a transcriptional repressor activity by cooperating with EPC1. Induces apoptosis by activating Jun N-terminal kinase and p38 kinase and also increases caspase-3-like activity independently of mitochondrial events. May function in male germ cell development. Has DNA-binding activity and preferentially bound to double-stranded DNA..

Immunogen: tripartite motif-containing 27

Synonyms: Ret finger protein, RFP, RING finger protein 76, RNF76, TRIM27, tripartite motif containing 27, Zinc finger protein RFP

Reactivity: Human, Mouse, Rat

Tested Application: ELISA, WB, IHC, IP, IF

Recommended dilution: WB: 1:500-1:2000; IP: 1:500-1:5000; IHC: 1:20-1:200; IF: 1:20-1:200

Image 1: Immunohistochemistry of paraffin-embedded human lung cancer using FNab08977(TRIM27 antibody) at dilution of 1:100

Image 2: Immunofluorescent analysis of HeLa cells using FNab08977 (TRIM27 antibody) at dilution of 1:50 and Alexa Fluor 488-conjugated Goat Anti-Rabbit IgG(H+L).

Image 3:

Image 4: Jurkat cells were subjected to SDS PAGE followed by western blot with FNab08977(TRIM27 antibody) at dilution of 1:1000

Gene ID: 5987

Research Area: Metabolism

Uniprot ID: P14373