anti- TRIM33 antibody

Product Description

anti- TRIM33 antibody is available at Gentaur for Next week Delivery.

Purification: Immunogen affinity purified

Background: Acts as an E3 ubiquitin-protein ligase. Promotes SMAD4 ubiquitination, nuclear exclusion and degradation via the ubiquitin proteasome pathway. According to PubMed:16751102, does not promote a decrease in the level of endogenous SMAD4. May act as a transcriptional repressor. Inhibits the transcriptional response to TGF-beta/BMP signaling cascade. Plays a role in the control of cell proliferation. Its association with SMAD2 and SMAD3 stimulates erythroid differentiation of hematopoietic stem/progenitor(By similarity). Monoubiquitinates SMAD4 and acts as an inhibitor of SMAD4-dependent TGF-beta/BMP signaling cascade(Monoubiquitination of SMAD4 hampers its ability to form a stable complex with activated SMAD2/3 resulting in inhibition of TGF-beta/BMP signaling cascade)..

Immunogen: tripartite motif-containing 33

Synonyms: Ectodermin homolog, FLJ32925, KIAA1113, Protein Rfg7, PTC7, RET fused gene 7 protein, RFG7, TF1G, TIF1 gamma, TIF1G, TIF1GAMMA, TIFGAMMA, TRIM33, tripartite motif containing 33

Reactivity: Human

Tested Application: ELISA, WB

Recommended dilution: WB: 1:200-1:2000

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Image 4: COLO 320 cells were subjected to SDS PAGE followed by western blot with FNab08981(TRIM33 antibody) at dilution of 1:500

Gene ID: 51592

Research Area: Metabolism

Uniprot ID: Q9UPN9