anti- TRIM63 antibody

Product Description

anti- TRIM63 antibody is available at Gentaur for Next week Delivery.

Purification: Immunogen affinity purified

Background: E3 ubiquitin ligase. Mediates the ubiquitination and subsequent proteasomal degradation of CKM, GMEB1 and HIBADH. Regulates the proteasomal degradation of muscle proteins under amino acid starvation, where muscle protein is catabolized to provide other organs with amino acids. Inhibits de novo skeletal muscle protein synthesis under amino acid starvation. Regulates proteasomal degradation of cardiac troponin I/TNNI3 and probably of other sarcomeric-associated proteins. May play a role in striated muscle atrophy and hypertrophy by regulating an anti-hypertrophic PKC-mediated signaling pathway. May regulate the organization of myofibrils through TTN in muscle cells..

Immunogen: tripartite motif-containing 63

Synonyms: FLJ32380, IRF, Iris RING finger protein, MuRF 1, MURF1, MURF2, RING finger protein 28, RNF28, SMRZ, TRIM63, tripartite motif containing 63

Reactivity: Human, Mouse, Rat

Tested Application: ELISA, WB, IHC, IF

Recommended dilution: WB: 1:200-1:1000; IHC: 1:20-1:200; IF: 1:10-1:100

Image 1: Immunohistochemistry of paraffin-embedded human heart using FNab08992(TRIM63 antibody) at dilution of 1:50

Image 2: Immunofluorescent analysis of HeLa cells using FNab08992 (TRIM63 antibody) at dilution of 1:25 and Rhodamine-Goat anti-Rabbit IgG.

Image 3:

Image 4: mouse heart tissue were subjected to SDS PAGE followed by western blot with FNab08992(TRIM63 antibody) at dilution of 1:300

Gene ID: 84676

Research Area: Metabolism

Uniprot ID: Q969Q1