anti- TRK fused gene antibody

Product Description

anti- TRK fused gene antibody is available at Gentaur for Next week Delivery.

Purification: Immunogen affinity purified

Background: Protein TFG(TRK-fused gene protein) plays a role in regulating phosphotyrosine-specific phosphatase-1 activity. Mutations in TFG may have important clinical relevance for current therapeutic strategies to treat metastatic melanoma. Defects in TFG are a cause of thyroid papillary carcinoma(TPC), a common tumor of the thyroid that typically arises as an irregular, solid or cystic mass from otherwise normal thyroid tissue. Hereditary motor and sensory neuropathy with proximal dominant involvement(HMSN-P) is an autosomal-dominant neurodegenerative disorder characterized by widespread fasciculations, proximal-predominant muscle weakness, and atrophy followed by distal sensory involvement. Recent genetic investigation indicates that formation of TFG-containing cytoplasmic inclusions and concomitant mislocalization of TAR DNA-binding protein 43 kDa(TDP-43) underlie motor neuron degeneration in HMSN-P. Pathological overlap of proteinopathies involving TFG and TDP-43 highlights a new pathway leading to motor neuron degeneration..

Immunogen: TRK-fused gene

Synonyms: FLJ36137, Protein TFG, TF6, TFG, TRK fused gene, TRK fused gene protein, TRKT3

Reactivity: Human, Mouse, Rat

Tested Application: ELISA, WB, IHC

Recommended dilution: WB: 1:500-1:5000; IHC: 1:20-1:200; IF: 1:50-1:500

Image 1: Immunohistochemistry of paraffin-embedded human gliomas using FNab09001(TFG antibody) at dilution of 1:100

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Image 4: A549 cells were subjected to SDS PAGE followed by western blot with FNab09001(TFG antibody) at dilution of 1:400

Gene ID:

Research Area: Metabolism

Uniprot ID: Q92734