anti- Tuberin-Specific antibody

Product Description

anti- Tuberin-Specific antibody is available at Gentaur for Next week Delivery.

Purification: Immunogen affinity purified

Background: TSC2, also named as TSC4, FLJ43106 and LAM, acts as a GTPase-activating protein(GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity of mTORC1. In complex with TSC1, TSC2 inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling. TSC2 implicated as a tumor suppressor. It is involved in microtubule-mediated protein transport, but this seems to be due to unregulated mTOR signaling. TSC2 stimulates weakly the intrinsic GTPase activity of the Ras-related proteins RAP1A and RAB5 in vitro. Mutations in TSC2 lead to constitutive activation of RAP1A in tumors. Mutations in either TSC2 or the related TSC1(hamartin) gene cause tuberous sclerosis complex(TSC), an autosomal dominant disorder characterized by development of multiple, widespread non-malignant tumors. The antibody is specific to TSC2..

Immunogen: tuberous sclerosis 2

Synonyms: FLJ43106, LAM, TSC2, TSC4, Tuberin, tuberous sclerosis 2, Tuberous sclerosis 2 protein

Reactivity: Human, Mouse

Tested Application: ELISA, WB, IF, IHC

Recommended dilution: WB: 1:200-1:2000; IHC: 1:20-1:200?IF: 1:10-1:100

Image 1: Immunohistochemistry of paraffin-embedded human kidney slide using FNab09101(TSC2-Specific Antibody) at dilution of 1:50

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Image 4: mouse lung tissue were subjected to SDS PAGE followed by western blot with FNab09101(TSC2-Specific antibody) at dilution of 1:300

Gene ID: 7249

Research Area: Metabolism

Uniprot ID: P49815