anti- UBE2O antibody

Product Description

anti- UBE2O antibody is available at Gentaur for Next week Delivery.

Purification: Immunogen affinity purified

Background: E2/E3 hybrid ubiquitin-protein ligase that displays both E2 and E3 ligase activities and mediates monoubiquitination of target proteins(PubMed:23455153, PubMed:24703950). Negatively regulates TRAF6-mediated NF-kappa-B activation independently of its E2 activity(PubMed:23381138). Acts as a positive regulator of BMP7 signaling by mediating monoubiquitination of SMAD6, thereby regulating adipogenesis(PubMed:23455153). Mediates monoubiquitination at different sites of the nuclear localization signal(NLS) of BAP1, leading to cytoplasmic retention of BAP1. Also able to monoubiquitinate the NLS of other chromatin-associated proteins, such as INO80 and CXXC1, affecting their subcellular location(PubMed:24703950). Acts as a regulator of retrograde transport by assisting the TRIM27:MAGEL2 E3 ubiquitin ligase complex to mediate 'Lys-63'-linked ubiquitination of WASH1, leading to promote endosomal F-actin assembly(PubMed:23452853)..

Immunogen: ubiquitin-conjugating enzyme E2O

Synonyms: E2-230K, FLJ12878, KIAA1734, UBE2O, Ubiquitin carrier protein O, Ubiquitin protein ligase O

Reactivity: Human, Mouse

Tested Application: ELISA, WB

Recommended dilution: WB: 1:200-1:2000

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Image 4: HeLa cells were subjected to SDS PAGE followed by western blot with FNab09181(UBE2O antibody) at dilution of 1:500

Gene ID: 63893

Research Area: Metabolism

Uniprot ID: Q9C0C9