anti- UBE2V1 antibody

Product Description

anti- UBE2V1 antibody is available at Gentaur for Next week Delivery.

Purification: Immunogen affinity purified

Background: Has no ubiquitin ligase activity on its own. The UBE2V1-UBE2N heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through Lys-63. This type of poly-ubiquitination activates IKK and does not seem to involve protein degradation by the proteasome. Plays a role in the activation of NF-kappa-B mediated by IL1B, TNF, TRAF6 and TRAF2. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage. Promotes TRIM5 capsid-specific restriction activity and the UBE2V1-UBE2N heterodimer acts in concert with TRIM5 to generate 'Lys-63'-linked polyubiquitin chains which activate the MAP3K7/TAK1 complex which in turn results in the induction and expression of NF-kappa-B and MAPK-responsive inflammatory genes..

Immunogen: ubiquitin-conjugating enzyme E2 variant 1

Synonyms: CIR1, CROC 1, CROC1, UBE2V, UBE2V1, UEV 1, UEV1, UEV1A

Reactivity: Human, Mouse, Rat

Tested Application: ELISA, WB

Recommended dilution: WB: 1:500-1:2000

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Image 4: HeLa cells were subjected to SDS PAGE followed by western blot with FNab09187(CD44 antibody) at dilution of 1:1000

Gene ID: 7335

Research Area: Metabolism

Uniprot ID: Q13404