anti- UIMC1 antibody

Product Description

anti- UIMC1 antibody is available at Gentaur for Next week Delivery.

Purification: Immunogen affinity purified

Background: Ubiquitin-binding protein(PubMed:24627472). Specifically recognizes and binds 'Lys-63'-linked ubiquitin(PubMed:19328070, Ref.36). Plays a central role in the BRCA1-A complex by specifically binding 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks(DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. Also weakly binds monoubiquitin but with much less affinity than 'Lys-63'-linked ubiquitin. May interact with monoubiquitinated histones H2A and H2B; the relevance of such results is however unclear in vivo. Does not bind Lys-48'-linked ubiquitin. May indirectly act as a transcriptional repressor by inhibiting the interaction of NR6A1 with the corepressor NCOR1..

Immunogen: ubiquitin interaction motif containing 1

Synonyms: BRCA1 A complex subunit RAP80, RAP80, Receptor associated protein 80, RXRIP110, UIMC1, X2HRIP110

Reactivity: Human, Mouse

Tested Application: ELISA, WB, IF, IHC,IF

Recommended dilution: WB: 1:200-1:1000; IP: 1?200-1?2000?IHC: 1?20-1?200; IF: 1?10-1?100

Image 1: Immunohistochemistry of paraffin-embedded human testis tissue slide using FNab09247(UIMC1 Antibody) at dilution of 1:50

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Image 4: mouse colon tissue were subjected to SDS PAGE followed by western blot with FNab09247(UIMC1 antibody) at dilution of 1:300

Gene ID: 51720

Research Area: Metabolism

Uniprot ID: Q96RL1