anti- USP20 antibody

Product Description

anti- USP20 antibody is available at Gentaur for Next week Delivery.

Purification: Immunogen affinity purified

Background: Deubiquitinating enzyme involved in beta-2 adrenergic receptor(ADRB2) recycling. Acts as a regulator of G-protein coupled receptor(GPCR) signaling by mediating the deubiquitination beta-2 adrenergic receptor(ADRB2). Plays a central role in ADRB2 recycling and resensitization after prolonged agonist stimulation by constitutively binding ADRB2, mediating deubiquitination of ADRB2 and inhibiting lysosomal trafficking of ADRB2. Upon dissociation, it is probably transferred to the translocated beta-arrestins, possibly leading to beta-arrestins deubiquitination and disengagement from ADRB2. This suggests the existence of a dynamic exchange between the ADRB2 and beta-arrestins. Deubiquitinates DIO2, thereby regulating thyroid hormone regulation. Deubiquitinates HIF1A, leading to stabilize HIF1A and enhance HIF1A-mediated activity. Mediates deubiquitination of both 'Lys-48'-and 'Lys-63'-linked polyubiquitin chains..

Immunogen: ubiquitin specific peptidase 20

Synonyms: Deubiquitinating enzyme 20, hVDU2, KIAA1003, LSFR3A, Ubiquitin thiolesterase 20, USP20, VDU2

Reactivity: Human, Mouse, Rat

Tested Application: ELISA, WB, IHC, IP

Recommended dilution: WB: 1:200-1:2000; IHC: 1:20-1:200?IP: 1:200-1:2000

Image 1: Immunohistochemistry of paraffin-embedded human kidney using FNab09317(USP20 antibody) at dilution of 1:50

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Image 4: HepG2 cells were subjected to SDS PAGE followed by western blot with FNab09317(USP20 antibody) at dilution of 1:400

Gene ID: 10868

Research Area: Metabolism

Uniprot ID: Q9Y2K6