Product Description
anti- VPS4B antibody is available at Gentaur for Next week Delivery.
Purification: Immunogen affinity purified
Background: Involved in late steps of the endosomal multivesicular bodies(MVB) pathway. Recognizes membrane-associated ESCRT-III assemblies and catalyzes their disassembly, possibly in combination with membrane fission. Redistributes the ESCRT-III components to the cytoplasm for further rounds of MVB sorting. MVBs contain intraluminal vesicles(ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. In conjunction with the ESCRT machinery also appears to function in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and enveloped virus budding(HIV-1 and other lentiviruses). VPS4A/B are required for the exosomal release of SDCBP, CD63 and syndecan(PubMed:22660413)..
Immunogen: vacuolar protein sorting 4 homolog B(S. cerevisiae)
Synonyms: MIG1, Protein SKD1, SKD1, VPS4 2, VPS42, VPS4B
Reactivity: Human, Mouse, Rat
Tested Application: ELISA, WB, IF, IP
Recommended dilution: WB: 1:500-1:5000?IP: 1:500-1:5000?IF: 1:10-1:100
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Image 4: Y79 cells were subjected to SDS PAGE followed by western blot with FNab09446(VPS4B antibody) at dilution of 1:500
Gene ID: 9525
Research Area: Metabolism
Uniprot ID: O75351