anti- WNK4 antibody

Product Description

anti- WNK4 antibody is available at Gentaur for Next week Delivery.

Purification: Immunogen affinity purified

Background: Serine/threonine kinase which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival and proliferation. Acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively. Activates SCNN1A, SCNN1B, SCNN1D, SGK1, TRPV5 and TRPV6. Regulates the activity of the thiazide-sensitive Na-Cl cotransporter, SLC12A3, by phosphorylation which appears to prevent membrane trafficking of SLC12A3. Also inhibits the renal K(+) channel, KCNJ1, via a kinase-independent mechanism by which it induces clearance of the protein from the cell surface by clathrin-dependent endocytosis. WNK4 appears to act as a molecular switch that can vary the balance between NaCl reabsorption and K(+) secretion to maintain integrated homeostasis. Phosphorylates NEDD4L. Acts as a scaffold to inhibit SLC4A4 as well as CFTR activities and surface expression, recruits STK39 which mediates the inhibition(By similarity)..

Immunogen: WNK lysine deficient protein kinase 4

Synonyms: PHA2B, PRKWNK4, WNK4

Reactivity: Human

Tested Application: ELISA, WB

Recommended dilution: WB: 1:200-1:2000

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Image 4: mouse colon tissue were subjected to SDS PAGE followed by western blot with FNab09516(WNK4 Antibody) at dilution of 1:600

Gene ID: 65266

Research Area: Metabolism

Uniprot ID: Q96J92