anti- WRN antibody

Product Description

anti- WRN antibody is available at Gentaur for Next week Delivery.

Purification: Immunogen affinity purified

Background: Multifunctional enzyme that has both magnesium and ATP-dependent DNA-helicase activity and 3'->5' exonuclease activity towards double-stranded DNA with a 5'-overhang. Has no nuclease activity towards single-stranded DNA or blunt-ended double-stranded DNA. Binds preferentially to DNA substrates containing alternate secondary structures, such as replication forks and Holliday junctions. May play an important role in the dissociation of joint DNA molecules that can arise as products of homologous recombination, at stalled replication forks or during DNA repair. Alleviates stalling of DNA polymerases at the site of DNA lesions. Important for genomic integrity. Plays a role in the formation of DNA replication focal centers; stably associates with foci elements generating binding sites for RP-A(By similarity). Plays a role in double-strand break repair after gamma-irradiation..

Immunogen: Werner syndrome, RecQ helicase-like

Synonyms: DKFZp686C2056, DNA helicase, RecQ like type 3, Exonuclease WRN, RecQ protein like 2, RECQ3, RECQL2, RECQL3, WRN

Reactivity: Human

Tested Application: ELISA, WB

Recommended dilution: WB: 1:200-1:1000

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Image 4: MCF-7 cells were subjected to SDS PAGE followed by western blot with FNab09524(WRN Antibody) at dilution of 1:300

Gene ID: 7486

Research Area: Metabolism

Uniprot ID: Q14191