anti- YTHDC1 antibody

Product Description

anti- YTHDC1 antibody is available at Gentaur for Next week Delivery.

Purification: Immunogen affinity purified

Background: Regulator of alternative splicing that specifically recognizes and binds N6-methyladenosine(m6A)-containing RNAs(PubMed:26318451, PubMed:26876937, PubMed:25242552). M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in the efficiency of mRNA splicing, processing and stability(PubMed:26318451, PubMed:25242552). Acts as a key regulator of exon-inclusion or exon-skipping during alternative splicing via interaction with mRNA splicing factors SRSF3 and SRSF10(PubMed:26876937). Specifically binds m6A-containing mRNAs and promotes recruitment of SRSF3 to its mRNA-binding elements adjacent to m6A sites, leading to exon-inclusion during alternative splicing(PubMed:26876937). In contrast, interaction with SRSF3 prevents interaction with SRSF10, a splicing factor that promotes exon skipping: this prevents SRSF10 from binding to its mRNA-binding sites close to m6A-containing regions, leading to inhibit exon skipping during alternative splicing(PubMed:26876937). May also regulate alternative splice site selection(PubMed:20167602)..

Immunogen: YTH domain containing 1

Synonyms: KIAA1966, Putative splicing factor YT521, YT521, YT521 B, YTH domain containing 1, YTHDC1

Reactivity: Human, Mouse, Rat

Tested Application: ELISA, WB

Recommended dilution: WB: 1:200-1:1000

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Image 4: MCF-7 cells were subjected to SDS PAGE followed by western blot with FNab09571(YTHDC1 Antibody) at dilution of 1:300

Gene ID: 91746

Research Area: Metabolism

Uniprot ID: Q96MU7