anti- YTHDF2 antibody

Product Description

anti- YTHDF2 antibody is available at Gentaur for Next week Delivery.

Purification: Immunogen affinity purified

Background: Specifically recognizes and binds N6-methyladenosine(m6A)-containing RNAs, and regulates mRNA stability(PubMed:24284625, PubMed:26046440, PubMed:26318451). M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in the efficiency of mRNA splicing, processing and stability(PubMed:22575960, PubMed:24284625, PubMed:25412658, PubMed:25412661). Acts as a regulator of mRNA stability: binding to m6A-containing mRNAs results in the localization to mRNA decay sites, such as processing bodies(P-bodies), leading to mRNA degradation(PubMed:24284625, PubMed:26046440). Also acts as a promoter of cap-independent mRNA translation following heat shock stress: upon stress, relocalizes to the nucleus and specifically binds mRNAs with some m6A methylation mark at their 5'-UTR, protecting demethylation of mRNAs by FTO, thereby promoting cap-independent mRNA translation(PubMed:26458103)..

Immunogen: YTH domain family, member 2

Synonyms: CLL associated antigen KW 14, HGRG8, NY REN 2, YTH domain family protein 2, YTH domain family, member 2, YTHDF2

Reactivity: Human, Mouse, Rat

Tested Application: ELISA, WB, IF, IHC, IP

Recommended dilution: WB: 1:1000-1:10000; IF: 1:10-1:100; IP: 1:200-1:1000; IHC: 1:20-1:200

Image 1: Immunohistochemistry of paraffin-embedded human testis tissue slide using FNab09573(YTHDF2 Antibody) at dilution of 1:50

Image 2: Immunofluorescent analysis of Hela cells using FNab09573(YTHDF2 Antibody) at dilution of 1:25..

Image 3: IP result of anti-YTHDF2(IP: FNab09573, 4?g; Detection: FNab09573 1:500) with Jurkat cells 2000?g.

Image 4: Jurkat cells were subjected to SDS PAGE followed by western blot with FNab09573(YTHDF2 Antibody) at dilution of 1:5000

Gene ID: 51441

Research Area: Metabolism

Uniprot ID: Q9Y5A9