anti- ZCCHC6 antibody

Product Description

anti- ZCCHC6 antibody is available at Gentaur for Next week Delivery.

Purification: Immunogen affinity purified

Background: Uridylyltransferase that mediates the terminal uridylation of mRNAs with short(less than 25 nucleotides) poly(A) tails, hence facilitating global mRNA decay(PubMed:19703396, PubMed:25480299). Involved in microRNA(miRNA)-induced gene silencing through uridylation of deadenylated miRNA targets(PubMed:25480299). Also acts as a suppressor of miRNA biogenesis by mediating the terminal uridylation of some miRNA precursors, including that of let-7(pre-let-7). Uridylated pre-let-7 RNA is not processed by Dicer and undergo degradation. Pre-let-7 uridylation is strongly enhanced in the presence of LIN28A(PubMed:22898984). Due to functional redundancy between ZCCHC6 and ZCCHC11, the identification of the specific role of each of these proteins is difficult..

Immunogen: zinc finger, CCHC domain containing 6

Synonyms: DKFZp666B142, DKFZp686C11112, DKFZp686F119, DKFZp686I1269, HS2, KIAA1711, PAPD6, Terminal uridylyltransferase 7, TUT7, TUTase 7, ZCCHC6

Reactivity: Human, Mouse, Rat

Tested Application: ELISA, WB, IP

Recommended dilution: WB: 1:500-1:5000; IP: 1:500-1:5000

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Image 4: PC-3 cells were subjected to SDS PAGE followed by western blot with FNab09611(ZCCHC6 Antibody) at dilution of 1:1000

Gene ID: 79670

Research Area: Metabolism

Uniprot ID: Q5VYS8