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  • TTR Protein
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  • TTR Protein TTR Protein TTR Protein TTR Protein TTR Protein TTR Protein TTR Protein TTR Protein TTR Protein TTR Protein TTR Protein TTR Protein

    TTR Protein

    Stress Marq Biosciences

    MSRP:
    Now: €141,000.00
    (You save )
    (No reviews yet) Write a Review
    SKU:
    SPR-465E
    Availability:
    Next week
    Shipping:
    Calculated at Checkout
    Size:
    5x100 µg
    Species:
    Human
    Specificity:
    15.887 kDa
    Conjugate:
    No Tag
    Storage Temperature:
    -80ºC
    Purity:
    >95%

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    Product Description

    TTR Protein is available at Gentaur for Next week delivery.

    Description:  Human Recombinant Transthyretin Y78F Variant Protein Filaments

    Alternative Name(s):  Amyloid polyneuropathy Protein, Amyloidosis I Protein, ATTR Protein, Carpal tunnel syndrome 1 Protein, CTS Protein, CTS1 Protein, HEL111 Protein, HsT2651 Protein, PALB Protein, Prealbumin Protein, Prealbumin amyloidosis type I Protein, Prealbumin Thyroxine-binding Protein, TBPA Protein, Thyroxine binding prealbumin Protein, Transthyretin Protein, TTHY_HUMAN Protein,TTR Protein

    Research Area(s):  Alzheimer's Disease | Axon Markers | Cell Markers | Cell Signaling | Cytoskeleton | Microtubules | MT Associated Proteins | Neurodegeneration | Neuron Markers | Neuroscience | Tangles & Tau

    Nature:  Recombinant

    Accession Number: NP_000362.1

    Gene ID:  7276

    Swiss-Prot:  P02766 

    Applications Species:  WB | SDS-PAGE | In vivo assay | In vitro assay 

    Biological Activity: 

    Expression System: E. coli

    Protein Length:  Full length

    Amino Acid Sequence:

    Purification:  Ion-exchange Purified

    Storage Buffer:  PBS pH 7.4

    Concentration:  Lot/batch specific. See included datasheet.

    Shipping Temperature: Dry Ice. Shipping note: Product will be shipped separately from other products purchased in the same order.

    Other relevant information: For best results, sonicate immediately prior to use. Refer to the Neurodegenerative Protein Handling Instructions on our website, or on the product datasheet for further information..

    Certificate of Analysis: Certified >95% pure using SDS-PAGE analysis. 

    Cellular Localization:  Cytoplasm | Extracellular exosome | Extracellular Region | Lysosome

    Scientific Background:  Transthyretin is a transport protein in the serum and cerebospinal fluid that carried the thyroid hormone Thyroxine and retinol-binding protein bound to retinol. TTR misfolding and aggregation is known to be associated with the amyloiddiseases SSA, FAP and FAC (1-5). TTR is also thought to have beneficial side effects, such as binding to beta-amyloid protein, preventing beta-amyloid from accumulating into the plaques associated with Alzheimer's Disease (6). The mutant variant Y78F indicates a destabilization of the contacts between the alpha-helix and AB loop and the body of the molecule, potentially leading to applications in immne therapy for FAP (7).

    References: 1. Zeldenrust S.R., Benson M.D. (2010). Wiley. pp. 795–815. 2. Westermark P., Sletten K., Johansson B., Cornwell G.G. (1990). Proc. Natl. Acad. Sci. U.S.A. 87(7): 2843–5. 3. Andrade C. (1952). Brain. 75(3): 408–27. 4. Coelho T. (1996). Curr. Opin. Neurol. 9(5): 355–9. 5. Jacobson D.R, et. al. (1997). N. Engl. J. Med. 336(7): 466–73. 6. Li X. (2011). Mol Neurodegener. 6(1):79. 7. Terazaki H.,m et al. (2006) Lab Invest. 86(1): 23-31.

    Field of Use:  Not for use in humans. Not for use in diagnostics or therapeutics. For research use only.

    PubMed ID: 

    Published Application: 

    Published Species Reactivity: 

    "

    Product Videos

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    Size 5x100 µg
    Species Human
    Specificity 15.887 kDa
    Conjugate No Tag
    Storage Temperature -80ºC
    Purity >95%

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    TTR Protein
    Stress Marq Biosciences
    TTR Protein

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