Recombinant Human Beta-defensin 1 protein (DEFB1) (Active)

Product Description

Recombinant Human Beta-defensin 1 protein (DEFB1) (Active) is available at Gentaur for Next week Delivery.

Gene Name: DEFB1,BD1,HBD1

Alternative Names : BD-1, Defensin, beta 1

Expression Region : 22-68aa

AA Sequence : GNFLTGLGHR SDHYNCVSSG GQCLYSACPI FTKIQGTCYR GKAKCCK

Sequence Info : Partial

Tag Info : Tag-Free

Theoretical MW : 5.1 kDa

Storage Buffer : Lyophilized from a 0.2 µm filtered 20 mM PB, pH 7.4, 130 mM NaCl

Endotoxin Level : Less than 1.0 EU/µg as determined by LAL method.-

Biological Activity : The biological activity determined by a chemotaxis bioassay using CD34+ dendritic cells is in a concentration range of 100.0-1000.0 ng/ml.

Storage : Short term: -20°C; Long term: -80°C. Minimize freeze and thaw cycles.

Research Area : Microbiology 

Restriction : For Research Use Only. Not for use in diagnostic procedures, drug use, or for administration to humans or animals.

Relevance : Has bactericidal activity. {ECO:0000250}.

Function : Has bactericidal activity. May act as a ligand for C-C chemokine receptor CCR6. Positively regulates the sperm motility and bactericidal activity in a CCR6-dependent manner. Binds to CCR6 and triggers Ca2+ mobilization in the sperm which is important for its motility

Involvement in disease :

Subcellular location : Secreted, Membrane

Protein Families : Beta-defensin family

Tissue Specificity : Blood plasma. Sperm. Highly expressed in the lower head and midpiece of sperm. Significantly reduced levels found in the sperms of asthenozoospermia and leukocytospermia patients (at protein level).

Paythway :

Uniprot ID : P60022