Recombinant Human C-X-C motif chemokine 11 protein (CXCL11) (Active)

Product Description

Recombinant Human C-X-C motif chemokine 11 protein (CXCL11) (Active) is available at Gentaur for Next week Delivery.

Gene Name: CXCL11,ITAC,SCYB11,SCYB9B

Alternative Names : Beta-R1, Interferon gamma-inducible protein 9, IP-9, Interferon-inducible T-cell alpha chemoattractant, I-TAC

Expression Region : 22-94aa

AA Sequence : FPMFKRGRCL CIGPGVKAVK VADIEKASIM YPSNNCDKIE VIITLKENKG QRCLNPKSKQ ARLIIKKVER KNF

Sequence Info : Full Length of Mature Protein

Tag Info : Tag-Free

Theoretical MW : 8.3 kDa

Storage Buffer : Lyophilized from a 0.2 µm filtered PBS, pH 7.4

Endotoxin Level : Less than 1.0 EU/µg as determined by LAL method.-

Biological Activity : The biological activity determined by a chemotaxis bioassay using human IL-2 activated human T-lymphocytes is in a concentration range of 0.1-10 ng/ml.

Storage : Short term: -20°C; Long term: -80°C. Minimize freeze and thaw cycles.

Research Area : Immunology

Restriction : For Research Use Only. Not for use in diagnostic procedures, drug use, or for administration to humans or animals.

Relevance : Chemotactic for interleukin-activated T-cells but not unstimulated T-cells, neutrophils or monocytes. Induces calcium release in activated T-cells. Binds to CXCR3. May play an important role in CNS diseases which involve T-cell recruitment. May play a role in skin immune responses.

Function : Chemotactic for interleukin-activated T-cells but not unstimulated T-cells, neutrophils or monocytes. Induces calcium release in activated T-cells. Binds to CXCR3. May play an important role in CNS diseases which involve T-cell recruitment. May play a role in skin immune responses.

Involvement in disease :

Subcellular location : Secreted

Protein Families : Intercrine alpha (chemokine CxC) family

Tissue Specificity : High levels in peripheral blood leukocytes, pancreas and liver astrocytes. Moderate levels in thymus, spleen and lung. Low levels in placenta, prostate and small intestine. Also found in epidermal basal layer keratinocytes in skin disorders.

Paythway : Chemokinesignalingpathway

Uniprot ID : O14625