Recombinant Human Cyclic AMP-dependent transcription factor ATF-7 (ATF7)

Product Description

Recombinant Human Cyclic AMP-dependent transcription factor ATF-7 (ATF7) is available at Gentaur for Next week Delivery.

Gene Name: ATF7

Alternative Names : Activating transcription factor 7 Transcription factor ATF-A

Expression Region : 1-117aa

AA Sequence : MGDDRPFVCNATGCGQRFTNEDHLAVHKHKHEMTLKFGPARTDSVIIADQTPTPTRFLKNCEEVGLFNELASSFEHEFKKAADEDEKKARSRTVAKKLVVFRPRLFLLCFGIIFLIG

Sequence Info : Full Length of BC042363

Tag Info : N-terminal GST-tagged

Theoretical MW : 40.3 kDa

Storage Buffer : Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.

Endotoxin Level : Not tested-

Biological Activity : Not tested

Storage : Short term: -20°C; Long term: -80°C. Minimize freeze and thaw cycles.

Research Area : Epigenetics and Nuclear Signaling

Restriction : For Research Use Only. Not for use in diagnostic procedures, drug use, or for administration to humans or animals.

Relevance : Plays important functions in early cell signaling. Binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AG][AG]-3'), a sequence present in many viral and cellular promoters. Activator of the NF-ELAM1/delta-A site of the E-selectin promoter. Has no intrinsic transcriptional activity, but activates transcription on formation of JUN or FOS heterodimers. Also can bind TRE promoter sequences when heterodimerized with members of the JUN family. Isoform 4 acts as a dominant repressor of the E-selectin/NF-ELAM1/delta-A promoter. Isoform 5 acts as a negative regulator, inhibiting both ATF2 and ATF7 transcriptional activities. It may exert these effects by sequestrating in the cytoplasm the Thr-53 phosphorylating kinase, preventing activation.

Function : Plays important functions in early cell signaling. Binds the cAMP response element (CRE) (consensus

Involvement in disease :

Subcellular location : Nucleus, Nucleus, nucleoplasm

Protein Families : BZIP family

Tissue Specificity : Expressed in heart, lung and skeletal muscle. Isoform 4 is expressed in various tissues including heart, brain, placenta, lung and skeletal muscle. Highest levels in skeletal muscle. Lowest in lung and placenta.

Paythway :

Uniprot ID : P17544