Recombinant Human Endothelin-1 receptor (EDNRA), partial

Product Description

Recombinant Human Endothelin-1 receptor (EDNRA), partial is available at Gentaur for Next week Delivery.

Gene Name: EDNRA

Alternative Names : Endothelin A receptor;ET-A;ETA-R;hET-AR

Expression Region : 21-80aa

AA Sequence : DNPERYSTNLSNHVDDFTTFRGTELSFLVTTHQPTNLVLPSNGSMHNYCPQQTKITSAFK

Sequence Info : Partial

Tag Info : N-terminal 6xHis-tagged

Theoretical MW : 8.8 kDa

Storage Buffer : Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.

Endotoxin Level : Not tested-

Biological Activity : Not tested

Storage : Short term: -20°C; Long term: -80°C. Minimize freeze and thaw cycles.

Research Area : Signal Transduction

Restriction : For Research Use Only. Not for use in diagnostic procedures, drug use, or for administration to humans or animals.

Relevance : Receptor for endothelin-1. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger syst. The rank order of binding affinities for ET-A is: ET1 > ET2 >> ET3.

Function : Receptor for endothelin-1. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of binding affinities for ET-A is

Involvement in disease : Mandibulofacial dysostosis with alopecia (MFDA)

Subcellular location : Cell membrane, Multi-pass membrane protein

Protein Families : G-protein coupled receptor 1 family, Endothelin receptor subfamily, EDNRA sub-subfamily

Tissue Specificity : Isoform 1, isoform 3 and isoform 4 are expressed in a variety of tissues, with highest levels in the aorta and cerebellum, followed by lung, atrium and cerebral cortex, lower levels in the placenta, kidney, adrenal gland, duodenum, colon, ventricle and liver but no expression in umbilical vein endothelial cells. Within the placenta, isoform 1, isoform 2, isoform 3 and isoform 4 are expressed in the villi and stem villi vessels.

Paythway : Calciumsignalingpathway

Uniprot ID : P25101