Recombinant Human Glial cell line-derived neurotrophic factor protein (GDNF) (Active)

Product Description

Recombinant Human Glial cell line-derived neurotrophic factor protein (GDNF) (Active) is available at Gentaur for Next week Delivery.

Gene Name: GDNF

Alternative Names : hGDNF, ATF

Expression Region : 78-211aa

AA Sequence : SPDKQMAVLP RRERNRQAAA ANPENSRGKG RRGQRGKNRG CVLTAIHLNV TDLGLGYETK EELIFRYCSG SCDAAETTYD KILKNLSRNR RLVSDKVGQA CCRPIAFDDD LSFLDDNLVY HILRKHSAKR CGCI

Sequence Info : Full Length of Mature Protein

Tag Info : Tag-Free

Theoretical MW : 30.1 kDa

Storage Buffer : Lyophilized from a 0.2 m filtered 1 × PBS, pH 7.4, with 0.05 % Tween-20

Endotoxin Level : Less than 1.0 EU/µg as determined by LAL method.-

Biological Activity : The ED50 as determined by a cell proliferation assay using rat C6 cells is less than 0.1 ng/ml, corresponding to a specific activity of ? 5.0 × 107 IU/mg.

Storage : Short term: -20°C; Long term: -80°C. Minimize freeze and thaw cycles.

Research Area : Neuroscience 

Restriction : For Research Use Only. Not for use in diagnostic procedures, drug use, or for administration to humans or animals.

Relevance : Neurotrophic factor that enhances survival and morphological differentiation of dopaminergic neurons and increases their high-affinity dopamine uptake. {ECO:0000269|PubMed:8493557}.

Function : Neurotrophic factor that enhances survival and morphological differentiation of dopaminergic neurons and increases their high-affinity dopamine uptake.

Involvement in disease : Hirschsprung disease 3 (HSCR3); Congenital central hypoventilation syndrome (CCHS); Pheochromocytoma (PCC)

Subcellular location : Secreted

Protein Families : TGF-beta family, GDNF subfamily

Tissue Specificity : In the brain, predominantly expressed in the striatum with highest levels in the caudate and lowest in the putamen. Isoform 2 is absent from most tissues except for low levels in intestine and kidney. Highest expression of isoform 3 is found in pancreatic islets. Isoform 5 is expressed at very low levels in putamen, nucleus accumbens, prefrontal cortex, amygdala, hypothalamus and intestine. Isoform 3 is up-regulated in the middle temporal gyrus of Alzheimer disease patients while isoform 2 shows no change.

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Uniprot ID : P39905