Recombinant Human Indian hedgehog protein (IHH), partial (Active)

Product Description

Recombinant Human Indian hedgehog protein (IHH), partial (Active) is available at Gentaur for Next week Delivery.

Gene Name: IHH

Alternative Names : IHH,

Expression Region : 29-202aa

AA Sequence : II+GPGRVVGS RRRPPRKLVP LAYKQFSPNV PEKTLGASGR YEGKIARSSE RFKELTPNYN PDIIFKDEEN TGADRLMTQR CKDRLNSLAI SVMNQWPGVK LRVTEGWDED GHHSEESLHY EGRAVDITTS DRDRNKYGLL ARLAVEAGFD WVYYESKAHV HCSVKSEHSA AAKTGG

Sequence Info : Partial

Tag Info : Tag-Free

Theoretical MW : 19.8 kDa

Storage Buffer : Lyophilized from a 0.2 ?m filtered 1 × PBS, pH 7.4

Endotoxin Level : Less than 1.0 EU/µg as determined by LAL method.-

Biological Activity : The ED50 as determined by its ability to induce alkaline phosphatase production by C3H10T1/2(CCL-226) cells is 3.0-10 ?g/ml.

Storage : Short term: -20°C; Long term: -80°C. Minimize freeze and thaw cycles.

Research Area : Stem Cells 

Restriction : For Research Use Only. Not for use in diagnostic procedures, drug use, or for administration to humans or animals.

Relevance : Intercellular signal essential for a variety of patterning events during development. Binds to the patched (PTC) receptor, which functions in association with smoothened (SMO), to activate the transcription of target genes. Implicated in endochondral ossification: may regulate the balance between growth and ossification of the developing bones. Induces the expression of parathyroid hormone-related protein (PTHRP) (By similarity). {ECO:0000250}.

Function : Intercellular signal essential for a variety of patterning events during development. Binds to the patched (PTC) receptor, which functions in association with smoothened (SMO), to activate the transcription of target genes. Implicated in endochondral ossification

Involvement in disease : Brachydactyly A1 (BDA1); Acrocapitofemoral dysplasia (ACFD)

Subcellular location : Indian hedgehog protein N-product: Cell membrane, Lipid-anchor, Extracellular side, Note=The N-terminal peptide remains associated with the cell surface, SUBCELLULAR LOCATION: Indian hedgehog protein C-product: Secreted, extracellular space

Protein Families : Hedgehog family

Tissue Specificity : Expressed in embryonic lung, and in adult kidney and liver.

Paythway : Hedgehogsignalingpathway

Uniprot ID : Q14623