Recombinant Human Insulin-like growth factor-binding protein 5 protein (IGFBP5) (Active)

Product Description

Recombinant Human Insulin-like growth factor-binding protein 5 protein (IGFBP5) (Active) is available at Gentaur for Next week Delivery.

Gene Name: IGFBP5,IBP5

Alternative Names : IBP-5, IGFBP-5

Expression Region : 21-272aa

AA Sequence : LGSFVHCEPC DEKALSMCPP SPLGCELVKE PGCGCCMTCA LAEGQSCGVY TERCAQGLRC LPRQDEEKPL HALLHGRGVC LNEKSYREQV KIERDSREHE EPTTSEMAEE TYSPKIFRPK HTRISELKAE AVKKDRRKKL TQSKFVGGAE NTAHPRIISA PEMRQESEQG PCRRHMEASL QELKASPRMV PRAVYLPNCD RKGFYKRKQC KPSRGRKRGI CWCVDKYGMK LPGMEYVDGD FQCHTFDSSN VE

Sequence Info : Full Length of Mature Protein

Tag Info : Tag-Free

Theoretical MW : 28.6 kDa

Storage Buffer : Lyophilized from a 0.2 µm filtered PBS, pH 7.0

Endotoxin Level : Less than 1.0 EU/µg as determined by LAL method.-

Biological Activity : The ED50 as determined by its ability to inhibit IGF-II induced proliferation of MCF-7 cells is less than 0.4 ?g/ml, corresponding to a specific activity of ? 2500 IU/mg in the presence of 15 ng/ml of rHuIGF-II.

Storage : Short term: -20°C; Long term: -80°C. Minimize freeze and thaw cycles.

Research Area : Cancer

Restriction : For Research Use Only. Not for use in diagnostic procedures, drug use, or for administration to humans or animals.

Relevance : IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.

Function : IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.

Involvement in disease :

Subcellular location : Secreted

Protein Families :

Tissue Specificity : Osteosarcoma, and at lower levels in liver, kidney and brain.

Paythway :

Uniprot ID : P24593