Recombinant Human Interferon-induced transmembrane protein 1 (IFITM1), partial

Product Description

Recombinant Human Interferon-induced transmembrane protein 1 (IFITM1), partial is available at Gentaur for Next week Delivery.

Gene Name: IFITM1

Alternative Names : Dispanin subfamily A member 2a;DSPA2aInterferon-induced protein 17Interferon-inducible protein 9-27Leu-13 antigen; CD225

Expression Region : 1-36AA

AA Sequence : MHKEEHEVAVLGPPPSTILPRSTVINIHSETSVPDH

Sequence Info : Extracellular Domain

Tag Info : N-terminal GST-tagged

Theoretical MW : 31 kDa

Storage Buffer : Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.

Endotoxin Level : Not tested-

Biological Activity : Not tested

Storage : Short term: -20°C; Long term: -80°C. Minimize freeze and thaw cycles.

Research Area : Immunology

Restriction : For Research Use Only. Not for use in diagnostic procedures, drug use, or for administration to humans or animals.

Relevance : IFN-induced antiviral protein which inhibits the entry of viruses to the host cell cytoplasm, permitting endocytosis, but preventing subsequent viral fusion and release of viral contents into the cytosol. Active against multiple viruses, including influenza A virus, SARS coronavirus (SARS-CoV), Marburg virus (MARV), Ebola virus (EBOV), Dengue virus (DNV), West Nile virus (WNV), human immunodeficiency virus type 1 (HIV-1) and hepatitis C virus (HCV). Can inhibit: influenza virus hagglutinin protein-mediated viral entry, MARV and EBOV GP1,2-mediated viral entry and SARS-CoV S protein-mediated viral entry. Also implicated in cell adhesion and control of cell growth and migration. Plays a key role in the antiproliferative action of IFN-gamma either by inhibiting the ERK activation or by arresting cell growth in G1 phase in a p53-dependent manner. Acts as a positive regulator of osteoblast differentiation

Function : IFN-induced antiviral protein which inhibits the entry of viruses to the host cell cytoplasm, permitting endocytosis, but preventing subsequent viral fusion and release of viral contents into the cytosol. Active against multiple viruses, including influenza A virus, SARS coronavirus (SARS-CoV), Marburg virus (MARV), Ebola virus (EBOV), Dengue virus (DNV), West Nile virus (WNV), human immunodeficiency virus type 1 (HIV-1) and hepatitis C virus (HCV). Can inhibit

Involvement in disease :

Subcellular location : Cell membrane, Single-pass membrane protein

Protein Families : CD225/Dispanin family

Tissue Specificity : Bone (at protein level). Levels greatly elevated in colon cancer, cervical cancer, esophageal cancer and ovarian cancer. Expressed in glioma cell lines.

Paythway : Bcellreceptorsignalingpathway

Uniprot ID : P13164