Recombinant Human Interleukin-20 protein (IL20) (Active)

Product Description

Recombinant Human Interleukin-20 protein (IL20) (Active) is available at Gentaur for Next week Delivery.

Gene Name: IL20,ZCYTO10,UNQ852/PRO1801

Alternative Names : IL-20,

Expression Region : 25-176aa

AA Sequence : M+LKTLNLGSC VIATNLQEIR NGFSEIRGSV QAKDGNIDIR ILRRTESLQD TKPANRCCLL RHLLRLYLDR VFKNYQTPDH YTLRKISSLA NSFLTIKKDL RLCHAHMTCH CGEEAMKKYS QILSHFEKLE PQAAVVKALG ELDILLQWME ETE

Sequence Info : Full Length of Mature Protein

Tag Info : Tag-Free

Theoretical MW : 17.6 kDa

Storage Buffer : Lyophilized from a 0.2 µm filtered PBS, pH 7.2, with trehalose

Endotoxin Level : Less than 1.0 EU/µg as determined by LAL method.-

Biological Activity : The ED50 as determined by a cell proliferation assay using human IL-20R? and human IL-20R? co-transfected murine BaF3 pro-B cells is less than 0.5 ng/ml, corresponding to a specific activity of ? 2.0 ×106 IU/mg.

Storage : Short term: -20°C; Long term: -80°C. Minimize freeze and thaw cycles.

Research Area : Immunology

Restriction : For Research Use Only. Not for use in diagnostic procedures, drug use, or for administration to humans or animals.

Relevance : Proinflammatory and angiogenic cytokine that may be involved in epidermal function and psoriasis. Angiogenic and proliferative activities are antagonized by IL10. May act through STAT3. {ECO:0000269|PubMed:16511554}.

Function : Proinflammatory and angiogenic cytokine that may be involved in epidermal function and psoriasis. Angiogenic and proliferative activities are antagonized by IL10. May act through STAT3.

Involvement in disease :

Subcellular location : Secreted

Protein Families : IL-10 family

Tissue Specificity : Expressed in most tissues and five major cell types: epithelial cells (primarily skin, buccal mucosa, tongue, nasal mucosa, lung, ureter, breast, prostate, fallopian tube, and adrenal gland), myoepithelial cells (mainly prostate), endothelial cells (mainly in small vessels or capillaries), macrophages, and skeletal muscle. Isoform 2 was detected in the lung tissue only.

Paythway : Jak-STATsignalingpathway

Uniprot ID : Q9NYY1