Recombinant Human Multidrug resistance-associated protein 1 (ABCC1), partial

Product Description

Recombinant Human Multidrug resistance-associated protein 1 (ABCC1), partial is available at Gentaur for Next week Delivery.

Gene Name: ABCC1

Alternative Names : ATP-binding cassette sub-family C member 1 Leukotriene C(4) transporter

Expression Region : 1248-1531aa

AA Sequence : VRMSSEMETNIVAVERLKEYSETEKEAPWQIQETAPPSSWPQVGRVEFRNYCLRYREDLDFVLRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHDLRFKITIIPQDPVLFSGSLRMNLDPFSQYSDEEVWTSLELAHLKDFVSALPDKLDHECAEGGENLSVGQRQLVCLARALLRKTKILVLDEATAAVDLETDDLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVIVLDKGEIQEYGAPSDLLQQRGLFYSMAKDAGLV

Sequence Info : Partial

Tag Info : N-terminal 6xHis-tagged

Theoretical MW : 35.9 kDa

Storage Buffer : Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.

Endotoxin Level : Not tested-

Biological Activity : Not tested

Storage : Short term: -20°C; Long term: -80°C. Minimize freeze and thaw cycles.

Research Area : Signal Transduction

Restriction : For Research Use Only. Not for use in diagnostic procedures, drug use, or for administration to humans or animals.

Relevance : Mediates export of organic anions and drugs from the cytoplasm. Mediates ATP-dependent transport of glutathione and glutathione conjugates, leukotriene C4, estradiol-17-beta-o-glucuronide, methotrexate, antiviral drugs and other xenobiotics. Confers resistance to anticancer drugs. Hydrolyzes ATP with low efficiency.

Function : Mediates export of organic anions and drugs from the cytoplasm. Mediates ATP-dependent transport of glutathione and glutathione conjugates, leukotriene C4, estradiol-17-beta-o-glucuronide, methotrexate, antiviral drugs and other xenobiotics. Confers resistance to anticancer drugs. Hydrolyzes ATP with low efficiency.

Involvement in disease :

Subcellular location : Cell membrane, Multi-pass membrane protein

Protein Families : ABC transporter superfamily, ABCC family, Conjugate transporter (TC 3.A.1.208) subfamily

Tissue Specificity : Lung, testis and peripheral blood mononuclear cells.

Paythway : Sphingolipidsignalingpathway

Uniprot ID : P33527