Recombinant Human Peptidyl-tRNA hydrolase ICT1, mitochondrial (ICT1)

Product Description

Recombinant Human Peptidyl-tRNA hydrolase ICT1, mitochondrial (ICT1) is available at Gentaur for Next week Delivery.

Gene Name: ICT1

Alternative Names : 39S ribosomal protein L58, mitochondrial;MRP-L58Digestion substraction 1;DS-1Immature colon carcinoma transcript 1 protein

Expression Region : 30-206aa

AA Sequence : LHKQKDGTEFKSIYSLDKLYPESQGSDTAWRVPNGAKQADSDIPLDRLTISYCRSSGPGGQNVNKVNSKAEVRFHLATAEWIAEPVRQKIAITHKNKINRLGELILTSESSRYQFRNLADCLQKIRDMITEASQTPKEPTKEDVKLHRIRIENMNRERLRQKRIHSAVKTSRRVDMD

Sequence Info : Full Length of Mature Protein

Tag Info : N-terminal 6xHis-SUMO-tagged

Theoretical MW : 36.4 kDa

Storage Buffer : Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.

Endotoxin Level : Not tested-

Biological Activity : Not tested

Storage : Short term: -20°C; Long term: -80°C. Minimize freeze and thaw cycles.

Research Area : Metabolism

Restriction : For Research Use Only. Not for use in diagnostic procedures, drug use, or for administration to humans or animals.

Relevance : Essential peptidyl-tRNA hydrolase component of the mitochondrial large ribosomal subunit. Acts as a codon-independent translation release factor that has lost all stop codon specificity and directs the termination of translation in mitochondrion, possibly in case of abortive elongation. May be involved in the hydrolysis of peptidyl-tRNAs that have been praturely terminated and thus in the recycling of stalled mitochondrial ribosomes.

Function : Essential peptidyl-tRNA hydrolase component of the mitochondrial large ribosomal subunit. Acts as a codon-independent translation release factor that has lost all stop codon specificity and directs the termination of translation in mitochondrion, possibly in case of abortive elongation. May be involved in the hydrolysis of peptidyl-tRNAs that have been prematurely terminated and thus in the recycling of stalled mitochondrial ribosomes.

Involvement in disease :

Subcellular location : Mitochondrion

Protein Families : Prokaryotic/mitochondrial release factor family, Mitochondrion-specific ribosomal protein mL62 subfamily

Tissue Specificity : Down-regulated during the in vitro differentiation of HT29-D4 colon carcinoma cells.

Paythway :

Uniprot ID : Q14197