Recombinant Human Pleiotrophin protein (PTN) (Active)

Product Description

Recombinant Human Pleiotrophin protein (PTN) (Active) is available at Gentaur for Next week Delivery.

Gene Name: PTN,HBNF1,NEGF1

Alternative Names : PTN, HBBM, Heparin-binding growth factor 8, HBGF-8, Heparin-binding growth-associated molecule

Expression Region : 33-168aa

AA Sequence : GKKEKPEKKV KKSDCGEWQW SVCVPTSGDC GLGTREGTRT GAECKQTMKT QRCKIPCNWK KQFGAECKYQ FQAWGECDLN TALKTRTGSL KRALHNAECQ KTVTISKPCG KLTKPKPQAE SKKKKKEGKK QEKMLD

Sequence Info : Full Length of Mature Protein

Tag Info : Tag-Free

Theoretical MW : 15.3 kDa

Storage Buffer : Lyophilized from a 0.2 m filtered PBS, pH 7.4

Endotoxin Level : Less than 1.0 EU/µg as determined by LAL method.-

Biological Activity : The biological activity was measured by its ability to enhance neurite outgrowth of E16­E18 rat embryonic cortical neurons, when neurons were plated on 96 well culture plates that had been pre­coated with 100 µl/well of a solution of 5­10 µg/ml rHuPTN.

Storage : Short term: -20°C; Long term: -80°C. Minimize freeze and thaw cycles.

Research Area : Immunology

Restriction : For Research Use Only. Not for use in diagnostic procedures, drug use, or for administration to humans or animals.

Relevance : Secreted growth factor that induces neurite outgrowth and which is mitogenic for fibroblasts, epithelial, and endothelial cells. Binds anaplastic lymphoma kinase (ALK) which induces MAPK pathway activation, an important step in the anti-apoptotic signaling of PTN and regulation of cell proliferation. {ECO:0000269|PubMed:11278720, ECO:0000269|PubMed:1768439}.

Function : Secreted growth factor that induces neurite outgrowth and which is mitogenic for fibroblasts, epithelial, and endothelial cells

Involvement in disease :

Subcellular location : Secreted

Protein Families : Pleiotrophin family

Tissue Specificity : Osteoblast and brain.

Paythway :

Uniprot ID : P21246